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Bertrand TAVITIAN  

Professor of Medical Imaging

PU-PH Full professor

born on October 21th, 1958

PARCC Inserm U970 - HEGP Radiologie

email

+33 1 53 98 80 54

Centre de recherche PARCC - Inserm U970, 56 rue Leblanc, 75015 Paris, France

www.parcc.inserm.fr

Ultrasound Molecular Imaging MRI PET Angiogenesis Metabolism

last updated on June 8th, 2016
CURRENT RESEARCH PROJECTS:
1. Explore the relationship between tumor metabolism and vascularization by non invasive in vivo imaging (fundamental and translational research)
2. Understand the cardiotoxicity of anticancer drugs (fundamental research)
3. Translate preclinical imaging methods into clinical...
CURRENT RESEARCH PROJECTS:
1. Explore the relationship between tumor metabolism and vascularization by non invasive in vivo imaging (fundamental and translational research)
2. Understand the cardiotoxicity of anticancer drugs (fundamental research)
3. Translate preclinical imaging methods into clinical benefit for patients ( translational research)
3. In collaboration with Institut Langevin, develop a hybrid imaging instrument combining Ultrafast Ultrasoiund and Positron Emission Tomography (technological research)

CARREER SUMMARY
Current Position: Professor of Radiology and Medical Imaging (Professeur des Universités ¿ Praticien des Hôpitaux) at the Faculty of Medicine of Paris Descartes, head of the Molecular Imaging research Laboratory of the Research Centre of the European Georges Pompidou Hospital, and director of the Network of life animal imaging platforms of the University Paris Descartes.
Education: former student of the Ecole Normale Supérieure in Paris and trained as MD and Professor of Biochemistry & Biological Engineering. During twelve years was the head of the Laboratory for Experimental Molecular Imaging (Inserm U 1023 - CEA) and of the platform for innovative imaging technologies (PET, SPECT, CT and optical imaging) in small-animal imaging research in Orsay, France.
Research: in vivo molecular imaging of gene expression in neurology, inflammation and cancer, notably PET radiotracer development and validation of innovative instruments and methods for quantitative imaging in animals and Humans. A long-time interest in the use of nucleic acids (antisense, aptamers, interfering RNAs, ribozymes,etc) for imaging, both as biotechnological tools for imaging probe development and as pharmacologically active compounds.
Highlights: coordinated the European Network of excellence EMIL (European Laboratories for Molecular Imaging of Cancer) and the European Master in molecular imaging. Co-founder and first President of the European Society for Molecular Imaging (ESMI). Co-authored 110 publications in peer-reviewed journals, 18 book chapters, edited 2 books, holds 12 patents and received awards from the American Nuclear Society and the European Research Achievements in 1999, the Eurocancer great scientific prize in 2005 and the ESMI Award in 2007.
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Experience 
Research
Director PARCC Inserm U970
Education 
Habilitation for Conducti
Imaging
Paris Sud University
1999
MD
Medicine
Paris Descartes University
1985
Professorship Agrégation
Biochemistry and Biological Engineering
France (national)
1982
Highlights 
Financement - funding

France Life Imaging PETRUS - ANR

Involvement

Life Imaging Platform of Paris Descartes - Director

Financement - funding
Financer
€ amount
Project
Subject field
My role
Recieved in
ANR
960 000
France Life Imaging PETRUS
Hybrid bimodal imaging
Co-PI
2014
Involvement
My role
Member of
Location
Time period
Director
Life Imaging Platform of Paris Descartes
Paris Descartes
Since 2014
2016
Cell Sheet Transplantation for Esophageal Stricture Prevention after Endoscopic Submucosal Dissection in a Porci... Cell Sheet Transplantation for Esophageal Stricture Prevention after Endoscopic Submucosal Dissection in a Porcine Model.
Bellucci A, Camilleri S, Casanova A, Cellier C, Clement O, ... Bellucci A, Camilleri S, Casanova A, Cellier C, Clement O, Perrod G, Pidial L, Rahmi G, Tavitian B, Viel T
PloS one 2016
Designing 3D Mesenchymal Stem Cell Sheets Merging Magnetic and Fluorescent Features: When Cell Sheet Technology ... Designing 3D Mesenchymal Stem Cell Sheets Merging Magnetic and Fluorescent Features: When Cell Sheet Technology Meets Image-Guided Cell Therapy.
Autret G, Balvay D, Blondiaux E, Cellier C, Clément O, ... Autret G, Balvay D, Blondiaux E, Cellier C, Clément O, Cuenod CA, Gazeau F, Meresse B, Perretta S, Pidial L, Rahmi G, Silva AK, Tavitian B, Wilhelm C
Theranostics 2016
Dissolution Dynamic Nuclear Polarization Instrumentation for Real-time Enzymatic Reaction Rate Measurements by N... Dissolution Dynamic Nuclear Polarization Instrumentation for Real-time Enzymatic Reaction Rate Measurements by NMR.
Balzan R, Comment A, Fernandes L, Pidial L, Tavitian B, ... Balzan R, Comment A, Fernandes L, Pidial L, Tavitian B, Vasos PR
Journal of visual... Journal of visualized experiments : JoVE 2016
Evaluation of Antitumor Activity of Long-Circulating and pH-Sensitive Liposomes Containing Ursolic Acid in Anima... Evaluation of Antitumor Activity of Long-Circulating and pH-Sensitive Liposomes Containing Ursolic Acid in Animal Models of Breast Tumor and Gliosarcoma.
Balvay D, Braga FC, Cassali GD, Ferreira LA, Ferreira Ê, ... Balvay D, Braga FC, Cassali GD, Ferreira LA, Ferreira Ê, Garofalakis A, Leite EA, Lopes SC, Oliveira MC, Rocha TG, Tavitian B, Veloso ES
Integrative cance... Integrative cancer therapies 2016
Imaging ROS-induced modifications in living systems.
Ba¿i¿ G, Bridal L, De Spirito M, Maulucci G, Schmidt HH, ... Ba¿i¿ G, Bridal L, De Spirito M, Maulucci G, Schmidt HH, Tavitian B, Utsumi H, Viel T, Yalç¿n AS
Antioxidants &... Antioxidants & redox signaling 2016
Synthesis, radiolabeling with fluorine-18 and preliminary in vivo evaluation of a heparan sulphate mimetic as po... Synthesis, radiolabeling with fluorine-18 and preliminary in vivo evaluation of a heparan sulphate mimetic as potent angiogenesis and heparanase inhibitor for cancer applications.
Boisgard R, Caravano A, Dollé F, El Hadri A, Hinnen F, ... Boisgard R, Caravano A, Dollé F, El Hadri A, Hinnen F, Kuhnast B, Nancy-Portebois V, Petitou M, Richard S, Tavitian B
Organic & bio... Organic & biomolecular chemistry 2016
2015
Comparative biodistribution in mice of cyanine dyes loaded in lipid nanoparticles.
Bardet M, Bayle PA, Boisgard R, Mérian J, Tavitian B, ... Bardet M, Bayle PA, Boisgard R, Mérian J, Tavitian B, Texier I
European journal ... European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 2015
In Vivo Detection of Succinate by Magnetic Resonance Spectroscopy as a Hallmark of SDHx Mutations in Paraganglio... In Vivo Detection of Succinate by Magnetic Resonance Spectroscopy as a Hallmark of SDHx Mutations in Paraganglioma.
Amar L, Autret G, Banting B, Bellucci A, Benit P, ... Amar L, Autret G, Banting B, Bellucci A, Benit P, Buffet A, Burnichon N, Cuenod CA, Favier J, Fontaine S, Fournier L, Gimenez-Roqueplo AP, Halimi P, Janin M, Lussey-Lepoutre C, Morin A, Ottolenghi C, Robidel E, Rustin P, Tavitian B, Zinzindohoué F
Clinical cancer r... Clinical cancer research : an official journal of the American Association for Cancer Research 2015
In vivo imaging and characterization of [(18)F]DPA-714, a potential new TSPO ligand, in mouse brain and peripher... In vivo imaging and characterization of [(18)F]DPA-714, a potential new TSPO ligand, in mouse brain and peripheral tissues using small-animal PET.
Alfano B, Brunetti A, Coda AR, Dollé F, Gargiulo S, ... Alfano B, Brunetti A, Coda AR, Dollé F, Gargiulo S, Gramanzini M, Greco A, Panico M, Pappatà S, Quarantelli M, Roviello GN, Salvatore M, Tavitian B, Vicidomini C, Zannetti A
Nuclear medicine ... Nuclear medicine and biology 2015
Multimodal imaging reveals temporal and spatial microglia and matrix metalloproteinase activity after experiment... Multimodal imaging reveals temporal and spatial microglia and matrix metalloproteinase activity after experimental stroke.
Breyholz HJ, Dollé F, Faber C, Faust A, Hermann S, ... Breyholz HJ, Dollé F, Faber C, Faust A, Hermann S, Jacobs AH, Kopka K, Kuhlmann MT, Pappata S, Planas AM, Schäfers M, Sorokin LM, Tavitian B, Viel T, Vrachimis A, Wachsmuth L, Wagner S, Zinnhardt B
Journal of cerebr... Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2015
Multimodal In Vivo Imaging of Tumorigenesis and Response to Chemotherapy in a Transgenic Mouse Model of Mammary ... Multimodal In Vivo Imaging of Tumorigenesis and Response to Chemotherapy in a Transgenic Mouse Model of Mammary Cancer.
Alberini JL, Boisgard R, Dollé F, Guillermet S, Jego B, ... Alberini JL, Boisgard R, Dollé F, Guillermet S, Jego B, Kühnast B, Maroy R, Menet E, Rezaï K, Siquier K, Tavitian B, Thézé B, Urien S
Molecular imaging... Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging 2015
2014
CRABP1 provides high malignancy of transformed mesenchymal cells and contributes to the pathogenesis of mesenchy... CRABP1 provides high malignancy of transformed mesenchymal cells and contributes to the pathogenesis of mesenchymal and neuroendocrine tumors.
Chemeris G, Delektorskaya V, Dyakova N, Favorskaya I, Kainov Y, ... Chemeris G, Delektorskaya V, Dyakova N, Favorskaya I, Kainov Y, Komelkov A, Tavitian B, Tchevkina E, Trukhanova L, Zborovskaya I, Zhuravskaya A, Zueva E
Cell cycle (Georg... Cell cycle (Georgetown, Tex.) 2014
2013
Fusion of [(18)F]FDG PET with fluorescence diffuse optical tomography to improve validation of probes and tumor ... Fusion of [(18)F]FDG PET with fluorescence diffuse optical tomography to improve validation of probes and tumor imaging.
Czarny B, Dubois A, Ducongé F, Garofalakis A, Tavitian B, ... Czarny B, Dubois A, Ducongé F, Garofalakis A, Tavitian B, Thézé B
Molecular imaging... Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging 2013
Synthetic lipid nanoparticles targeting steroid organs.
Boisgard R, Decleves X, Mérian J, Tavitian B, Texier I, ... Boisgard R, Decleves X, Mérian J, Tavitian B, Texier I, Thezé B
Journal of nuclea... Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2013
The translocator protein radioligand 18F-DPA-714 monitors antitumor effect of erufosine in a rat 9L intracranial... The translocator protein radioligand 18F-DPA-714 monitors antitumor effect of erufosine in a rat 9L intracranial glioma model.
Awde AR, Boisgard R, Dollé F, Dubois A, Jacobs AH, ... Awde AR, Boisgard R, Dollé F, Dubois A, Jacobs AH, Tavitian B, Thézé B, Winkeler A, Zheng J
Journal of nuclea... Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2013
2012
Analysis of the growth dynamics of angiogenesis-dependent and -independent experimental glioblastomas by multimo... Analysis of the growth dynamics of angiogenesis-dependent and -independent experimental glioblastomas by multimodal small-animal PET and MRI.
Backes H, Bjerkvig R, Brekka N, Hoehn M, Jacobs AH, ... Backes H, Bjerkvig R, Brekka N, Hoehn M, Jacobs AH, Jikeli JF, Miletic H, Monfared P, Neumaier B, Niclou SP, Stieber D, Talasila KM, Tavitian B, Thorsen F, Viel T, Waerzeggers Y, Wang J, Winkeler A
Journal of nuclea... Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2012
Comparison of 18F-fluoro-deoxy-glucose, 18F-fluoro-methyl-choline, and 18F-DPA714 for positron-emission tomograp... Comparison of 18F-fluoro-deoxy-glucose, 18F-fluoro-methyl-choline, and 18F-DPA714 for positron-emission tomography imaging of leukocyte accumulation in the aortic wall of experimental abdominal aneurysms.
Alsac JM, Boisgard R, Hervatin F, Le Guludec D, Michel JB, ... Alsac JM, Boisgard R, Hervatin F, Le Guludec D, Michel JB, Montravers F, Sarda-Mantel L, Tavitian B
Journal of vascul... Journal of vascular surgery 2012
Imaging microglial/macrophage activation in spinal cords of experimental autoimmune encephalomyelitis rats by po... Imaging microglial/macrophage activation in spinal cords of experimental autoimmune encephalomyelitis rats by positron emission tomography using the mitochondrial 18 kDa translocator protein radioligand [¹¿F]DPA-714.
Abourbeh G, Boisgard R, Brulon V, Dollé F, Dubois A, ... Abourbeh G, Boisgard R, Brulon V, Dollé F, Dubois A, Fontyn Y, Maroy R, Tavitian B, Thézé B
The Journal of ne... The Journal of neuroscience : the official journal of the Society for Neuroscience 2012
Imaging of perfusion, angiogenesis, and tissue elasticity after stroke.
Boisgard R, Macé E, Martín A, Montaldo G, Tanter M, ... Boisgard R, Macé E, Martín A, Montaldo G, Tanter M, Tavitian B, Thézé B
Journal of cerebr... Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2012
Noninvasive molecular imaging of neuroinflammation.
Jacobs AH, Tavitian B
Journal of cerebr... Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2012
2011
Specific biomarkers of receptors, pathways of inhibition and targeted therapies: pre-clinical developments.
Faust A, Jacobs A, Kopka K, Monfared P, Schäfers M, ... Faust A, Jacobs A, Kopka K, Monfared P, Schäfers M, Tavitian B, Viel T, Waerzeggers Y, Winkeler A
The British journ... The British journal of radiology 2011